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Clinical trials for Degenerative Disease

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   43881   clinical trials with a EudraCT protocol, of which   7295   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    367 result(s) found for: Degenerative Disease. Displaying page 1 of 19.
    1  2  3  4  5  6  7  8  9  Next» Last»»
    EudraCT Number: 2004-000979-33 Sponsor Protocol Number: ITAES PR 2503 Start Date*: 2005-01-31
    Sponsor Name:LABORATOIRES EXPANSCIENCE
    Full Title: A multinational multicentre randomised paralle group study on therapeutic efficacy and tolerability of PIASCLEDINE capsules 300 mg in comparison with placebo in the treatment of hip osteoarthritis
    Medical condition: hip osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    6.1 10031161 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2007-003016-60 Sponsor Protocol Number: CSMC021C-2302 Start Date*: 2007-10-12
    Sponsor Name:Nordic Bioscience A/S
    Full Title: A Randomized, Double-Blind, Multi-Center, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Oral Salmon Calcitonin in the Treatment of Subjects with Knee Osteoarthritis.
    Medical condition: Osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    9.1 10031161 Osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed) BE (Completed) PL (Completed) GB (Completed) CZ (Prematurely Ended) ES (Completed)
    Trial results: View results
    EudraCT Number: 2008-008593-31 Sponsor Protocol Number: 2PX-OA-03 Start Date*: 2009-04-03
    Sponsor Name:SantoSolve A/S
    Full Title: A 26 week placebo-controlled, randomised, double-blind, parallel group study of the efficacy and safety of 2PX (topical strontium chloride hexahydrate) in patients with pain due to osteoarthritis o...
    Medical condition: pain associated with osteoarthritis of the knee
    Disease: Version SOC Term Classification Code Term Level
    9.1 10031161 Osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed) GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-002963-92 Sponsor Protocol Number: CLRX712A12201 Start Date*: 2020-02-05
    Sponsor Name:Novartis Pharma AG
    Full Title: A randomized, placebo-controlled, subject and investigator blinded study investigating the safety, tolerability and preliminary efficacy of 8-week treatment with intra-articular LRX712 to regenerat...
    Medical condition: Cartilage injuries
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10031161 Osteoarthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Restarted) AT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-001955-29 Sponsor Protocol Number: 024PKAN15004 Start Date*: Information not available in EudraCT
    Sponsor Name:Retrophin, Inc.
    Full Title: Efficacy, Safety, and Tolerability of Fosmetpantotenate (RE-024), a Phosphopantothenate replacement therapy, in patients with Pantothenate Kinase-associated Neurodegeneration (PKAN): A Randomized, ...
    Medical condition: Pantothenate kinase associated neurodegeneration (PKAN), an autosomal recessive genetic disorder, the most common form of Neurodegeneration with Brain Iron Accumulation (NBIA). It is a progressive,...
    Disease: Version SOC Term Classification Code Term Level
    21.1 10029205 - Nervous system disorders 10053643 Neurodegenerative disorder PT
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: DE (Completed) ES (Prematurely Ended) GB (Prematurely Ended) CZ (Prematurely Ended) NO (Completed) FR (Completed) PL (Prematurely Ended) IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-002494-75 Sponsor Protocol Number: CL3-12911-018 Start Date*: 2006-04-26
    Sponsor Name:Institut de Recherches Internationales Servier
    Full Title: The efficacy and safety of two doses of strontium ranelate (1g and 2g per day) versus placebo administered orally for 3 years in the treatment of knee osteoarthritis. A prospective multicentre, int...
    Medical condition: Osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    7.0 10031161 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) AT (Completed) BE (Completed) GB (Completed) ES (Completed) IT (Completed) DK (Completed) PT (Completed) LT (Completed) EE (Completed) CZ (Completed)
    Trial results: View results
    EudraCT Number: 2017-004049-26 Sponsor Protocol Number: MTX-071-P02 Start Date*: 2017-11-23
    Sponsor Name:Mestex
    Full Title: Lopain (MTX-071 / resiniferatoxin) An open label, single dose phase Ib/IIa study to determine the safety and clinical effects of intra-articular injections of low doses of Lopain (MTX-071) in pa...
    Medical condition: chronic osteoarthritic knee-joint pain
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10031161 Osteoarthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2006-005956-34 Sponsor Protocol Number: 0822-011 Start Date*: 2007-03-14
    Sponsor Name:Merck Sharp & Dohme Ltd
    Full Title: A Phase IIa Randomized, Placebo-Controlled Clinical Trial to Study the Safety and Efficacy of MK-0822 in Patients with Osteoarthritis
    Medical condition: Osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    8.1 10031161 Osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2004-001713-34 Sponsor Protocol Number: A3471119 Start Date*: 2005-01-11
    Sponsor Name:Pfizer Limited
    Full Title: RANDOMIZED, DOUBLE-BLIND, MULTICENTER STUDY OF THE EFFICACY, TOLERABILITY AND SAFETY OF VALDECOXIB (BEXTRA®)10 MG OD VS. DICLOFENAC SODIUM 50 MG TDS FOR 6 WEEKS IN SUBJECTS WITH OSTEOARTHRITIS OF T...
    Medical condition: Osteoarthritis of the knee
    Disease: Version SOC Term Classification Code Term Level
    10031161
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-003233-32 Sponsor Protocol Number: BUP4009 Start Date*: 2006-09-12
    Sponsor Name:Mundipharma AB
    Full Title: A randomized, open, controlled parallel group, multi-center study to evaluate the efficacy and safety of Norspan versus Tiparol Retard in subjects with chronic, moderate to severe osteoarthritis pa...
    Medical condition: Pain due to osteoarthritis of the hip and/or knee
    Disease: Version SOC Term Classification Code Term Level
    8.1 10031161 Osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2009-012442-23 Sponsor Protocol Number: Start Date*: 2009-11-18
    Sponsor Name:Dorset County Hospital NHS foundation trust
    Full Title: Intraarticular injections for hip osteoarthritis: Steroid versus Hyaluronic acid: randomised controlled trial
    Medical condition: Osteoarthritis of hip joint
    Disease: Version SOC Term Classification Code Term Level
    9.0 10031161 osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2010-020748-37 Sponsor Protocol Number: BUP4504 Start Date*: 2010-12-01
    Sponsor Name:Mundipharma AB
    Full Title: An open label, multi-centre, prospective age-group-controlled study to evaluate efficacy and safety of buprenorphine transdermal patches in subjects with chronic, moderate to severe osteoarthritis ...
    Medical condition: Osteoarthritis pain
    Disease: Version SOC Term Classification Code Term Level
    12.1 10031161 Osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2011-003232-31 Sponsor Protocol Number: TDU11685-ACT12505 Start Date*: 2011-11-03
    Sponsor Name:sanofi-aventis recherche et développement
    Full Title: A two part protocol to assess, using double blind placebo control, the safety, tolerability, and pharmacokinetics of ascending single doses of a new intra-articular administration formulation of SA...
    Medical condition: KNEE OSTEOARTHRITIS
    Disease: Version SOC Term Classification Code Term Level
    14.0 10028395 - Musculoskeletal and connective tissue disorders 10031161 Osteoarthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2010-024315-14 Sponsor Protocol Number: 95609379 Start Date*: 2011-01-04
    Sponsor Name:Tekonivelsairaala Coxa
    Full Title: Paikallispuudutus polven tekonivelleikkauksen yhteydessä - vähentynyt opiaattien kulutus leikkauksen jälkeen ja nopeampi liikeharjoituksen aloitus - kaksoissokkotutkimus
    Medical condition: Polven nivelrikko.
    Disease: Version SOC Term Classification Code Term Level
    12.1 10031174 Osteoarthrosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-000623-27 Sponsor Protocol Number: EC_01_2017 Start Date*: 2017-09-11
    Sponsor Name:Fundacion para la investigacion biomedica HUPA
    Full Title: Role of autologous biological therapy in knee osteoarthritis. Intraosseous application of plasma rich in growth factors , improve of functional capacity and pain, compared to intraarticular applic...
    Medical condition: Knee osteoarthritis.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10031161 Osteoarthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-004194-10 Sponsor Protocol Number: CL3-12911-028 Start Date*: 2006-11-07
    Sponsor Name:Institut de Recherches Internationales Servier
    Full Title: Long-term effects of strontium ranelate on knee osteoarthritis symptoms. A 2-year prospective, randomised, placebo-controlled study.
    Medical condition: Osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    9.0 10031161 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2017-000178-13 Sponsor Protocol Number: RDORTH01 Start Date*: 2017-04-13
    Sponsor Name:Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust
    Full Title: How Effective are Topical NSAIDs in the Treatment of Hip Osteoarthritis: An In Vivo Study in Patients Undergoing Total Hip Arthroplasty
    Medical condition: Osteoarthritis of the hip
    Disease: Version SOC Term Classification Code Term Level
    19.1 100000004859 10031167 Osteoarthritis NOS LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2011-004046-18 Sponsor Protocol Number: CL3-12911-040 Start Date*: 2012-02-23
    Sponsor Name:Institut de Recherches Internationales Servier
    Full Title: Knee joint replacement over 5 years in patients with knee osteoarthritis. A long term follow up study in patients of the CL3-12911-018 study.
    Medical condition: Osteoarthritis The medical condition investigated in the CL3-12911-018 study was osteoarthritis. The applied CL3-12911-040 trial, CL3-12911-018 follow-up study, is thus performed in osteoarthrit...
    Disease: Version SOC Term Classification Code Term Level
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10031161 Osteoarthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) DE (Prematurely Ended) AT (Completed) BE (Completed) PL (Prematurely Ended) ES (Prematurely Ended) IT (Prematurely Ended) DK (Prematurely Ended) LT (Prematurely Ended) PT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-003286-17 Sponsor Protocol Number: CCOX189A2428 Start Date*: 2006-01-04
    Sponsor Name:Novartis Pharma Services AG
    Full Title: A 4-week, multicentre, randomized, double-blind, double-dummy, parallel group ambulatory blood pressure monitoring study to demonstrate that treatment with lumiracoxib 100 mg o.d. results in an imp...
    Medical condition: Osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    8.0 10031161 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) AT (Completed) SE (Completed) GB (Completed) FI (Completed)
    Trial results: View results
    EudraCT Number: 2013-003467-60 Sponsor Protocol Number: M13-741 Start Date*: 2014-06-11
    Sponsor Name:AbbVie Deutschland GmbH & Co. KG
    Full Title: A Phase 2a Study Evaluating the Safety, Efficacy, and Pharmacodynamic Effects of ABT-981 in Patients with Knee Osteoarthritis
    Medical condition: Adult male and female patients with mild to moderate, symptomatic, radiographic and inflammatory osteoarthritis of the knee
    Disease: Version SOC Term Classification Code Term Level
    18.0 10028395 - Musculoskeletal and connective tissue disorders 10031161 Osteoarthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed) GB (Completed) NL (Completed) ES (Completed) IT (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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